Multiple Sclerosis (MS) Research Team
Name and Credentials: Elizabeth S. Gromisch, PhD, MSCS
Title: Research Neuropsychologist
Affiliations: Frank H. Netter MD School of Medicine at Quinnipiac University, University of Connecticut School of Medicine, VA Connecticut Healthcare System, UConn Center for mHealth and Social Media
Elizabeth S. Gromisch, PhD, MSCS is a Harry Weaver Scholar of the National Multiple Sclerosis Society and research neuropsychologist at the Joyce D. and Andrew J. Mandell Center for Comprehensive Multiple Sclerosis Care and Neuroscience Research at Mount Sinai Rehabilitation Hospital, Trinity Health Of New England. She also holds appointments at the University of Connecticut School of Medicine and the Frank H. Netter MD School of Medicine, and maintains an affiliation with VA Connecticut Healthcare System. Dr. Gromisch’s research interests include using mHealth to deliver behavioral interventions to people with multiple sclerosis (MS), understanding factors related to treatment adherence and self-management behaviors, and improving cognitive screening procedures. She is a co-developer of the Multiple Sclerosis Resiliency Scale (MSRS), the first multidimensional measure of resiliency to MS-related challenges, which is currently being translated and investigated in other countries.
- Development and feasibility of a fatigue self-management mHealth program for persons with multiple sclerosis (Managing My MS My Way: Fatigue)
- Development and evaluation of MSCogScreen: a multi-domain, MS-specific cognitive screening tool
- Development of a cognition self-management mHealth program for persons with multiple sclerosis (Managing My MS My Way: Cognition)
- Examination of appointment attendance behaviors before and after the implementation of the VEText program in Veterans with multiple sclerosis
- Gromisch, E.S., Turner, A.P., Neto, L.O., Haselkorn, J.K., & Raskin, S.A. (2024). Improving prospective memory in persons with multiple sclerosis via telehealth: a randomized feasibility study. Multiple Sclerosis and Related Disorders. 88: 105718. doi: 10.1016/j.msard.2024.105718.
- Gromisch, E.S., Neto, L.O., DelMastro, H.M., Dhari, Z., Pisa, M., & Turner, A.P. (2023). Physical activity and life stress are associated with illness intrusiveness in persons with multiple sclerosis. Archives of Physical Medicine and Rehabilitation. doi: 10.1016/j.apmr.2023.10.020.
- Gromisch, E.S., Ehde, D.M., Neto, L.O., Haselkorn, J.K., Agresta, T., Gokhale, S.S., & Turner, A.P. (2023). Using participatory action research to develop a new self-management program: results from the design stage of Managing My MS My Way. Multiple Sclerosis and Related Disorders. 74: 104720. doi: 10.1016/j.msard.2023.104720.
- Gromisch, E.S., Turner, A.P., Neto, L.O., Haselkorn, J.K., & Raskin, S.A. (2023). Identifying prospective memory deficits in multiple sclerosis: preliminary evaluation of the criterion and ecological validity of a single item version of the Memory for Intentions Test (MIST). The Clinical Neuropsychologist. 37: 371-386. doi: 10.1080/13854046.2022.2062451.
- Gromisch, E.S., Raskin, S.A., Neto, L.O., Haselkorn, J.K., & Turner, A.P. (2023). Appointment attendance behaviors in multiple sclerosis: understanding the factors that differ between no shows, short notice cancellations, and attended appointments. Multiple Sclerosis and Related Disorders. 70: 104509. doi: 10.1016/j.msard.2023.104509.
- Gromisch, E.S., Turner, A.P., Neto, L.O., Ruiz, J.A., Lo, A.C., Agresta, T., & Foley, F.W. (2023). Establishing the test-retest reliability and minimal detectable change of the Multiple Sclerosis Resiliency Scale (MSRS). International Journal of MS Care. 25: 15-19. doi: 10.7224/1537-2073.2021-126.
- Gromisch, E.S., Neto, L.O., & Turner, A.P. (2021). What biopsychosocial factors explain self-management behaviors in multiple sclerosis? The role of demographics, cognition, personality, and psychosocial and physical functioning. Archives of Physical Medicine and Rehabilitation. 102: 1982-1988. doi: 10.1016/j.ampr.2021.05.012
- Gromisch, E.S. & Foley, F.W. (2020). Can semantic fluency be used as an alternative or additional measure in the abbreviated Minimal Assessment of Cognitive Function in Multiple Sclerosis (aMACFIMS)? Journal of the Neurological Sciences. 410. doi: 10.1016/j.jns.2019.116640.
- Gromisch, E.S., Turner, A.P., Leipertz, S.L., Beauvais, J., & Haselkorn, J.K. (2020). Who is not coming to clinic? A predictive model of excessive missed appointments in persons with multiple sclerosis. Multiple Sclerosis and Related Disorders. 38. doi: 10.1016/j.msard.2019.101514.
- Gromisch, E.S., Sloan, J., Zemon, V., Tyry, T., Schairer, L.C., Snyder, S., & Foley, F.W. (2018). Development of the Multiple Sclerosis Resiliency Scale (MSRS). Rehabilitation Psychology. 63: 357-364. doi:10.1037/rep0000219.
Name and Credentials: Zaenab Dhari, MD
Title: Multiple Sclerosis Fellow
Affiliations: UConn Health, Department of Neuroscience, University of Connecticut (Assistant Professor), Frank Netter School of Medicine, Quinnipiac University
Zaenab Dhari, MD is a Multiple Sclerosis Fellow. Dr. Dhari’s journey began with developmental neuroscience, where a keen interest in brain development and function laid the foundation for her current research endeavors. Building on this foundation, and the role of progenitor cells in response to stress in various neurological diseases, she has been dedicating her research to understand remyelination failure through unravelling metabolic pathways in MS which is a potential target for a therapeutic intervention. In addition to her interest in understanding oligodendrocytes repair capacity, Dr. Dhari is also interested in understanding the interplay between cardiac risk factors and autonomic dysregulation in MS and their impact on electrophysiological and structural cardiac manifestations. Dr. Dhari’s work encompasses basic research that delves into the molecular and cellular mechanisms underlying MS, translational research that bridges the gap between laboratory discoveries and clinical applications, and clinical research that strives to improve patient outcomes through innovative therapeutic strategies.
- The Role of Tetrahydrobiopterin (BH4) in Demyelination and Remyelination.
- Plasma Level of Tetrahydrobiopterin (BH4) in MS in Relation to Disease stage, Activity and Progression.
- The Prevalence and Types of Electrophysiological (ECG) Patterns in MS.
- The Interaction Between Cardiac Risk Factors and Autonomic Dysregulation on Cardiac Electrophysiological and Structural Changes in MS.
- Desai, M. H., Ceneri, N. M., Dhari, Z., Tongut, A., Ozturk, M., Staffa, S. J., Zurakowski, D., Schidlow, D., Sinha, P., & Jonas, R. A. (2023). Cardiac surgical outcomes of patients with heterotaxy syndrome. JTCVS open, 13, 292-306.
- Dhari, Z., Leonetti, C., Lin, S., Prince, A., Howick, J., Zurakowski, D., Wang, P. C., Jonas, R. A., & Ishibashi, N. (2021). Impact of cardiopulmonary bypass on neurogenesis and cortical maturation. Annals of neurology, 90(6), 913-926.
- Dhari, Z., Paro, A., Huselid, R., Paradis, D., Laddaran, L., Munoz, J. G., Thomson, E., Tabtabai, S., Bailey, M., & Gromisch, E. S. (2022). Prevalence and Types of Resting Electrocardiography (ECG) Findings in Persons with Multiple Sclerosis (PwMS). 2022 Annual Meeting of the Consortium of Multiple Sclerosis Centers,
- Dhari, Z., Pisa, M., Neto, L., Paro, A., Bailey, M., De Luca, G., & Ruiz, J. (2022). A stable cohort of relapsing remitting multiple sclerosis (RRMS) has reduced tetrahydrobiopterin (BH4) In plasma. MULTIPLE SCLEROSIS JOURNAL,
- Dhari, Z., Pisa, M., Neto, L., Paro, A., Bailey, M., De Luca, G. C., & Ruiz, J. (2022). Tetrahydrobiopterin (BH4) Plasma Level is Reduced in a Clinically Stable Cohort of Relapsing Remitting Multiple Sclerosis (RRMS). Annals of neurology,
- Gromisch, E. S., Neto, L. O., DelMastro, H. M., Dhari, Z., Pisa, M., & Turner, A. P. (2024). Physical activity and life stress are associated with illness intrusiveness in persons with multiple sclerosis. Archives of Physical Medicine and Rehabilitation, 105(5), 876-883.
- Maeda, T., Sarkislali, K., Leonetti, C., Kapani, N., Dhari, Z., Al Haj, I., Ulrey, R., Hanley, P. J., Jonas, R. A., & Ishibashi, N. (2020). Impact of mesenchymal stromal cell delivery through cardiopulmonary bypass on postnatal neurogenesis. The Annals of thoracic surgery, 109(4), 1274-1281.
- Nguyen, C. A., Raskin, S. A., Turner, A. P., Dhari, Z., Neto, L. O., & Gromisch, E. S. (2024). Patterns of prospective memory errors differ in persons with multiple sclerosis. Journal of clinical and experimental neuropsychology, 1-12.
- Romanowicz, J., Guerrelli, D., Dhari, Z., Mulvany, C., Reilly, M., Swift, L., Vasandani, N., Ramadan, M., Leatherbury, L., & Ishibashi, N. (2021). Chronic perinatal hypoxia delays cardiac maturation in a mouse model for cyanotic congenital heart disease. American Journal of Physiology-Heart and Circulatory Physiology, 320(5), H1873-H1886.
- Romanowicz, J., Leonetti, C., Dhari, Z., Korotcova, L., Ramachandra, S. D., Saric, N., Morton, P. D., Bansal, S., Cheema, A., & Gallo, V. (2019). Treatment with tetrahydrobiopterin improves white matter maturation in a mouse model for prenatal hypoxia in congenital heart disease. Journal of the American Heart Association, 8(15), e012711.
Name and Credentials: Lindsay Neto, MPH
Title and Affiliations: Research Associate III, Mandell Center for Multiple Sclerosis; Instructor, Department of Rehabilitation Medicine and Medical Sciences, Frank H. Netter MD School of Medicine at Quinnipiac University
Lindsay earned her undergraduate in biomedical sciences at Quinnipiac University in Hamden, CT. She completed her Master’s in Public Health at the University of Massachusetts Amherst. Lindsay’s research interests lie in population health and well-being with a focus on comorbid conditions, lifestyle, and quality of life research in persons with multiple sclerosis.
- Development of the Lifestyle and Preventative Health Index Value in Multiple Sclerosis
- PI: Lindsay Neto, MPH
- Co-I: Elizabeth Gromisch, PhD and Heather DelMastro, MS
- Multiple sclerosis disease characteristics across the spectrum of care
- PI: Lindsay Neto, MPH
- Characterization of perceived health-related quality of life and healthcare resource utilization in persons with multiple sclerosis with and without vascular comorbidity
- PI: Lindsay Neto, MPH
- Co-I: Elizabeth S. Gromisch, PhD
- Development of a risk factor model for self-management skills among persons with multiple sclerosis
- PI: Elizabeth S. Gromisch, PhD
- Co-I: Lindsay Neto, MPH
- Development of a self-management program for persons with multiple sclerosis
- PI: Elizabeth S. Gromisch, PhD
- Co-I: Lindsay Neto, MP
- Neto LO, Ruiz JA, Gromisch ES. Perceived Health-Related Quality of Life in Persons with Multiple Sclerosis with and without a Vascular Comorbidity. Quality of Life Research. 2023
- Gromisch ES, Neto LO, DelMastro HM, Dhari Z, Pisa M, Turner, AP. Physical activity and life stress are associated with illness intrusiveness in persons with multiple sclerosis. Physical Medicine and Rehabilitation. Archives of Physical Medicine and Rehabilitation. 2023. (In Press).
- Gromisch ES, Turner AP, Leipertz SL, Neto LO, Beauvis J, Haselkorn JK. Comorbidities as Predictors of All-Cause Emergency Department Utilization among Veterans with Multiple Sclerosis. Multiple Sclerosis and Related Disorders. 2022.
- Gromisch ES, Neto LO, and Turner AP. What biopsychosocial factors explain self-management behaviors in multiple sclerosis? The role of demographics, cognition, personality, and psychosocial and physical functioning. Archives of Physical Medicine and Rehabiliation. 2021.
- Neto LO, Ruiz JA, Gromisch ES. Neto LO, Gromisch ES, Sloan J, Tyry T, Foley FW. The Relationship Between Aspects of Resiliency and Intimacy-Related Illness Intrusiveness in Males with Multiple Sclerosis. Sex Disabil. 2020; 38: 135–145.
- Neto LO, Gromisch ES, Sloan J, Tyry T, Foley FW. Sex Differences in Predictors of Illness intrusiveness in Persons with Multiple Sclerosis. Qual Life Res. 2019 Feb; 28(2): 389-397Quality of Life Research. 2023
Name and Credentials: Heather M. DelMastro, MS, CSCS
Title: Research Associate II
Affiliations: Mandell MS Center, Mount Sinai Rehabilitation Hospital, Trinity Health Of New England; Department of Rehabilitation Medicine, Frank H. Netter MD School of Medicine at Quinnipiac University
Heather M DelMastro has over ten years of research experience, with a strong background in exercise science, interventional studies, and functional measures. Her research in Multiple Sclerosis focuses on upper and lower limb function, strength, physical activity, falls, gait, and balance. She also has a track record of establishing standardized assessments and a high inter- and intra-rater reliability, with experience in recruiting, consenting, data collection and management, and preparing data for presentation and publication. Heather mentors Doctor of Physical Therapy Students through their research Capstones starting at the development of the idea through the literature review, methods, scientific writing, statistical analysis, interpretation, and dissemination of the project.
- Examine the Feasibility, Validity, and Reliability of the Five Times Sit to Stand Test via Telehealth in a neurological patient population
IRB # MSH-22-01- PI: Heather M. DelMastro
- Status: Closed to Enrollment, Data analysis phase
- Establishment of Normative Isometric Strength Values for the Lower Extremity in Persons with Multiple Sclerosis
IRB # MSH-18-23- PI: Heather M. DelMastro
- Status: Closed to Enrollment, Data analysis phase
- Characterizing Upper Extremity Function in Individuals with Multiple Sclerosis
IRB # 13-12-002-E- PI: Heather M. DelMastro
- Status: Closed to Enrollment, Data analysis phase
- Intermittent vs. continuous walking training in people with multiple sclerosis: a comparison of effectiveness
IRB # MSH-18-73- PI: Heather M. DelMastro
- Status: Closed to Enrollment, Data analysis phase
- DelMastro HM, Robson A, Gromsich ES, Campo M, Simaitis LB, Lo AC, Dhari Z, Ruiz J.A. Establishment of regression-based isometric strength reference values for the upper limb in persons with multiple sclerosis. PM R. 2024 Jul 12. doi: 10.1002/pmrj.13234. Epub ahead of print. PMID: 38995022.
- Gromisch ES, Neto LO, DelMastro HM, Dhari Z, Pisa M, Turner AP Physical Activity and Life Stress Are Associated With Illness Intrusiveness in Persons With Multiple Sclerosis. Arch Phys Med Rehabil. 2024 May;105(5):876-883. doi: 10.1016/j.apmr.2023.10.020. Epub 2023 Nov 14. PMID: 37967667.
- Rubel A, DelMastro HM, Ruiz JA, Lo AC, Gromisch ES. Using Objective and Subjective Measures of Cognition to Predict Instrumental Activities of Daily Living Abilities in Multiple Sclerosis. Int J MS Care. 2024 May-Jun;26(3):113-118. doi: 10.7224/1537-2073.2023-023. Epub 2024 May 16. PMID: 38765299; PMCID: PMC11096855.
- DelMastro HM, Simaitis LB, Gromisch ES, Gomes K, Ruiz JA. Establishment of regression-based normative isometric strength values for major lower limb muscle groups in persons with multiple sclerosis. Mult Scler Relat Disord. 2023 Jul;75:104772. doi: 10.1016/j.msard.2023.104772. Epub 2023 May 24. PMID: 37247487.
- DelMastro HM, Ruiz JA, Simaitis LB, Gromisch ES, Neto LO, Cohen ET, Wong E, Krug RJ, Lo AC. Effect of Backward and Forward Walking on Lower Limb Strength, Balance, and Gait in Multiple Sclerosis: A Randomized Feasibility Trial. Int J MS Care. 2023 Mar-Apr;25(2):45-50. doi: 10.7224/1537-2073.2022-010. Epub 2022 Oct 3. PMID: 36923577; PMCID: PMC10010109.
- Pisa M, Ruiz JA, DeLuca, GC, de Andres Crespo, DelMastro HM, Olson KM, Triche EW, Lo AC. Quantification of upper limb dysfunction in the activities of the daily living in persons with multiple sclerosis. Mult Scler Relat Disord. 2022 Jul;63:103917. doi: 10.1016/j.msard.2022.103917. Epub 2022 Jun 1. PMID: 35671673.
- Gomes KE, Ruiz JA, Raskin SA, Turner AP, DelMastro HM, Neto LO, Gromisch ES. The Role of Cognitive Impairment on Physical Therapy Attendance and Outcomes in Multiple Sclerosis. J Neurol Phys Ther. 2022 Jan 1;46(1):34-40. doi: 10.1097/NPT.0000000000000375. PMID: 34507342.
- DelMastro HM, Ruiz JA, Gromisch ES, Garbalosa JC, Triche EW, Olson KM, Lo AC. Quantification characteristics of digital spiral analysis for understanding the relationship among tremor and clinical measures in persons with multiple sclerosis. J Neurosci Methods. 2018 Sep 1;307:254-259. doi: 10.1016/j.jneumeth.2018.06.016. Epub 2018 Jun 22. PMID: 29940199.
Name and Credentials: Carolyn St. Andre, BS
Title and Affiliations: Research Associate I, Mandell Center for Multiple Sclerosis
Carolyn earned her Bachelors of Science in Toxicology at Northeastern University in Boston, MA in 2007. Carolyn started her research career in obstetrics under the Director of Perinatal Services at Mercy Medical Center in Springfield, then transitioned to her current focus on multiple sclerosis at the Mandell MS Center in 2011. Carolyn’s role focuses on registry projects and management of data abstraction for contribution to longitudinal data sets.
- Retrospective Chart Review of Disease Characteristics in Multiple Sclerosis
- PI: Carolyn St. Andre